Presnel Kimpembe and Idrissa Gueye are set to be sidelined after sustaining injuries against Montpellier last weekend.
Defender Kimpembe was substituted after 18 minutes after suffering an injury to his left hamstring. He is expected to return to training early January.
Midfielder Gueye also sustained a hamstring injury and is expected to return to training after 12 days.
There is good news for Marco Verratti, Ander Herrera and Edison Cavani.
Marco Verrati has missed PSG’s past two games but returned to training on Monday. Uruguay forward Edison Cavani will also join the team this week after missing PSG’s 3-1 at the weekend.
Former Manchester United midfielder Ander Herrera is set to return to full training at the end of the week after missing in action for a month due to a thigh injury.
Paris St Germain will face Galatasaray in the UEFA Champions League on Wednesday before facing St Etienne on Sunday in the French Ligue 1.